Antibodies secreted by terminally differentiated plasma cells are critical for immune defense in the tumor microenvironment, which labels tumor cells and induces macrophage‐ and NK‐cell‐dependent malignant cell‐killing effects.[5b,22] We observed increased infiltration levels of NK cells (Figure 5E), and macrophages (Figure 5F) in HCC tissues upon adoptive transfer of CXCR4+ B cells combined with CXCL12 treatment. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.