Pre‐mRNA processing factor 19 (PRP19) is a critical member of the PRP19‐associated complex that exerts multiple biological functions,[9] such as DNA damage response,[10] tumor radiotherapy resistance,[11] and protein ubiquitin.[12] However, the relationship between PRP19 expression and B cell function in the TME of HCC is largely unclear. Here, PRPF19 is linked to hepatocellular carcinoma.