Kaplan–Meier analysis indicated that high expression of PRP19 and low expression of CD20 in HCC patients had poor prognosis in the TCGA‐LIHC dataset (Figure S1G, Supporting Information) and Gao's cohort (Figure S1H, Supporting Information), and patients with high PRP19 and low CD20 levels had the worst prognosis (Figure S1I, Supporting Information). Here, PRPF19 is linked to hepatocellular carcinoma.