CXCL12 and hepatocellular carcinoma: Moreover, several studies have reported that DDX5 regulates the transcriptional processing of target genes by maintaining RNA stability.[23b,28] Therefore, to assess the impact of DDX5 on CXCL12 mRNA stability, we inhibited RNA transcription using Actinomycin D (ActD) and examined CXCL12 mRNA levels in DDX5 overexpression and knockdown HCC cells.