By exploring the TCGA‐LIHC dataset, we found that PRP19 and UBE2I expression levels were increased in HCC tissues (Figure S1B, Supporting Information), and PRP19 was negatively correlated with CD20 expression (R = −0.35, p = 7.2e–15, Figure S1C, Supporting Information). Here, PRPF19 is linked to hepatocellular carcinoma.