First, we investigated the expression of CXCL12 and CXCR4 in HCC microenvironment using published single‐cell sequencing data, which included myeloid cells (CD14 and CD68), T cells (CD3D and CD3G), B cells (CD79A and MS4A1), malignant cells (AFP and GPC3), endothelial cells (PECAM1 and CDH5).[19] B cells displayed the most abundant expression of CXCR4, and a high level of CXCR4 was also shown in myeloid cells and T cells. This evidence concerns the gene PECAM1 and hepatocellular carcinoma.