CXCL12‐α is the most widespread splicing variant and can manage the hematopoietic stem cell (HSC) population in the bone marrow.[25] CXCL12‐β is associated with angiogenic properties.[26] CXCL12‐γ is mainly localized within the nucleus and has potent anti‐HIV activity.[27] To examine whether DDX5 regulates CXCL12 RNA alternative splicing, we assessed CXCL12‐α, CXCL12‐β, and CXCL12‐γ expression levels in DDX5 overexpression and knockdown HCC cells. Here, CXCL12 is linked to hepatocellular carcinoma.