The interaction between CXCL12 and CXCR4 induces CD47 internalization and promotes tumor cell phagocytosis by macrophages in mesothelioma tumors.[37] Exogenous treatment of cervical cancer cells with CXCL12 in vitro inhibited cell metastasis and growth events.[38] Besides, High CXCL12 expression was associated with better prognostic outcomes in breast cancer and endometrial cancer patients.[39] In the present study, we found that the CXCL12/CXCR4 axis is critical for PRP19 meditated B cell enrichment in HCC. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.