Activation of the STING pathway can lead to the excessive production of pro-inflammatory cytokines, including type I interferons (e.g., IFN-α, IFN-β) and non-type I interferons such as IFN-γ, causing severe side effects like fever, chills, and cytokine release syndrome (CRS). This evidence concerns the gene IFNB1 and congenital rubella syndrome.