Melanoma antigens that can be recognized by T-cells are classified as follows: (a) tumor-specific neo-antigens derived from DNA mutations, (b) cancer-germline antigens, which are tumor-specific shared antigens (3), melanocyte-specific differentiation antigens (e.g. gp100, MART-1, tyrosinase, TRP-1, TRP-2) and (4) other antigens such as viral antigens or overexpressed proteins (8). The gene discussed is TYR; the disease is melanoma.