GSDMD and Sepsis: A recent study confirmed that factors related to the classical NLPR3/ASC/caspase-1/GSDMD pathway are involved in pyroptosis, as they are highly expressed in the cells of both humans and animals with sepsis, and the use of blockers or knockouts of related factors in this pathway can attenuate the systemic inflammatory response, thus preventing damage to organ function to a certain extent [33].