Notably, a study on the ACE-Inhibitory activity of soy protein isolates in the prevention of hypertension in an in vivo model showed that, when 25 g of non-soy protein were substituted with 25 g of soy nuts (i.e., soy nuts containing 25 g of soy protein and 101 mg of aglycone isoflavones), hypertensive women and normotensive postmenopausal women’s blood pressure increased, all of which were attributed to the cardioprotective effect (Margatan et al., 2013; Welty et al., 2007). Here, ACE is linked to hypertensive disorder.