A mechanistic study revealed that SF (56.4 or 282 μmol/kg/day for 6 days/week for 8 weeks) cleared Aβ and tau accumulation by increasing levels of a heat shock protein (HSP70) and co-chaperone (CHIP), and mitigated memory deficits in a triple transgenic mouse model of AD (66). The gene discussed is MAPT; the disease is Alzheimer disease.