INS and Cowden syndrome 1: -No other causes of HA such as Hyper PRL, CS, CAH-Exclusion criteria: presence of serious concomitant illness, based on clinical examination and routine laboratory findings, including DM, other endocrine and metabolic disturbances, eating disorders, use of OCP, Insulin-sensitizing, glucose lowering,lipid-lowering or psychoactive medications within 6 months from assessment