Multiple fatty hepatic genes patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13), and membrane-bound O-acyltransferase domain-containing protein 7 ((MBOAT7) also known as lysophospholipid acyltransferase 7) are responsible for the development NAFLD and NASH have been identified [195-197]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatohepatitis.