Other medications are approved for rare obesity subtypes, as opposed to general obesity, such as Metreleptin for congenital or acquired generalized lipodystrophy and Setmelanotide for individuals with genetic variants of obesity (e.g., proopiomelanocortin, proprotein convertase subtilisin/kexin type 1, leptin receptor). The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.