JMJD6 and neoplasm: JMJD6 is a JmjC family nuclear protein with both arginine demethylation and lysine hydroxylation activities regulating RNA alternative splicing processes, cancer progression and embryo development.3,4,9–12 According to the TCGA SpliceSeq database, tumors compared to normal tissues may have different preference in the alternative termination of JMJD6.13 For example, tumor samples in glioblastoma (GBM) showed 86.4 PSI (Percent Spliced-In) at exon 7.2 and 13.4 PSI at exon 8.