Somatic variants attributing to tumorigenesis and having a possible disease prognostic value had been identified in genes including, TP53, EP300, NFE2L2, CSMD3, CCND1, CDKN2A, CREBBP, RB1, KMT2D, KMT2C, KDM6A, FAT1, FAT2, FAT3, FAT4, AJUBA, NOTCH1, NOTCH2, NOTCH3, FBXW7, PTCH1 and PIK3CA [2–4] Additionally, limited published work has however shown germline variants in TP53, BRCA1, BRCA2 and RECQL4 contributing to familial cases of ESCC [5, 6]. The gene discussed is BRCA2; the disease is esophageal squamous cell carcinoma.