GLD patients (FBN1, ADAMTSL2, or LTBP3 gene defect) have characteristic facial features, including a happy face with full cheeks, a short nose, hypertelorism, a long flat philtrum, a thin upper lip, tracheal stenosis that may require tracheostomy, hepatomegaly, and progressive cardiac valvular thickening, which leads to reduced life expectancy if left untreated. This evidence concerns the gene FBN1 and stricture.