Several lines of evidence suggest that genes involved in the JAK-STAT pathway are involved in autoimmune diseases, including a decrease in autoantibody titers is associated with inhibition of the JAK-STAT pathway (Wang et al., 2010[16]), STAT4-deficient mice are resistant to models of autoimmune disease (Finnegan et al., 2002[5]), and susceptibility to autoimmune disease is associated with polymorphisms in the TYK2 and STAT4 genes (Remmers et al., 2007[12]; Liang et al., 2012[9]; Ebrahimiyan et al., 2019[4]; Pellenz et al., 2021[11]). Here, STAT4 is linked to autoimmune disease.