As it is well-known, the PI3K/AKT signaling pathway plays a crucial role in regulating various cellular processes such as growth, proliferation, survival, and metabolism, aberrant activation of this pathway is frequently observed in atrophic gastritis (Navaei et al., 2022[40]; Xie and Liu, 2018[60]). The gene discussed is AKT1; the disease is chronic atrophic gastritis.