This aberrant activation leads to increased expression of transforming growth factor-alpha (TGF-α), followed by up-regulation of epidermal growth factor receptor (EGFR) and abnormal expression of TFF-α, disrupting the normal proliferation regulation of cells and consequently promoting the progression of precancerous lesions to gastric cancer (Chaturvedi et al., 2014[4]; Filipe et al., 1995[10]). This evidence concerns the gene TGFA and gastric cancer.