In mammals, the protein Seipin is encoded by the Berardinelli-Seip Congenital Lipodystrophy type 2 (BSCL2) gene, and its loss-of-function results in severe lipodystrophy in humans characterized by selective loss of adipose tissue, and seipinopathy, neurological disorders affecting motor neurons, which garnered an immense interest in its role in LD biogenesis (Cartwright and Goodman, 2012; Magre et al., 2001; Szymanski et al., 2007; Windpassinger et al., 2004). Here, BSCL2 is linked to lipodystrophy.