CREB1 and melanoma: Molecular genetic techniques have afforded indisputable evidence that CCS is genetically distinct from malignant melanoma due to the cytogenic hallmarks of t(12;22) (q13;q12) or less commonly a t(2;22) (q34;q12) translocation, forming chimeric EWSR1::ATF1 or EWSR1::CREB1 fusions in CCS, which are not found in melanoma.2