CTSO and ischemic stroke: Conversely, elevated levels of Cathepsin E (OR: 1.05, 95%CI: 1.01, 1.09, p = 0.015) and Cathepsin O (OR: 1.05, 95%CI: 1.01, 1.10, p = 0.021) were associated with an increased risk of ischemic stroke.