In these mice, hippocampal inoculation of sarkosyl insoluble human brain derived PSP tau generated all three PSP-related cytopathologies as early as 1 month post inoculation, with spread to the contralateral hemisphere at 6 months post inoculation (Xu et al., 2021; He et al., 2020). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.