MAPT and supranuclear palsy, progressive, 1: However, the model with most relevance for PSP is the hTau-40/P301L rat, which develops mild deposition of hyperphosphorylated insoluble tau associated with dendritic abnormalities with no degeneration and minimal behavioral deficits, making them particularly appropriate for examining early “pretangle” pathology (Korhonen et al., 2009).