Studies have used a variety of methods to extract tau from human PSP brains, including PBS as well as varying percentages of sarkosyl (0.1–2%) (Clavaguera et al., 2013; Narasimhan et al., 2020, 2017; Xu et al., 2021; He et al., 2020; Ferrer et al., 2019). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.