Importantly, the structure of misfolded tau has been shown to be distinct among the major tauopathies (Shi et al., 2021), yet to date only six inoculation studies in mice have used PSP tau, summarized in Table 1 (Narasimhan et al., 2020, 2017; Clavaguera et al., 2013; Xu et al., 2021; He et al., 2020; Ferrer et al., 2019). Here, MAPT is linked to tauopathy.