MAPT and supranuclear palsy, progressive, 1: Although to date, there are no transgenic rodents that spontaneously develop the three key tau cytopathologies, behavioral phenotype or neurodegeneration seen in PSP, the mice generated to date do each offer an opportunity to study some critical aspect of the disease, be it related to specific genetic factors or an opportunity to selectively focus on neuronal, oligodendroglial or astrocytic pathology.