However, following reports identifying the A152T tau mutation as a risk factor for several tauopathies, including AD and PSP, Carlomangno et al. used somatic brain transgenesis to compare the effects of AAV-A152T and AAV-P301L tau in mouse brain (Carlomagno et al., 2019). Here, MAPT is linked to supranuclear palsy, progressive, 1.