MAPT and supranuclear palsy, progressive, 1: Thus, an ideal animal model of PSP would: (a) exist on a background that mirrors the expression of all isoforms of tau expressed in the human brain, (b) mimic the three key early cytopathologies of all subtypes of PSP in the pallido-nigro-luysian axis, (c) recapitulate key structural and biochemical features of PSP-tau, (d) exhibit neurodegeneration and an accompanying locomotor behavioral phenotype (e) use methodologies that are both reproducible and scalable.