Although we don't have a full understanding of how these exclusive structural characteristics of PSP tau might influence the distinct cell type specific pathology found in PSP, it's plausible that the unique disease relevant tau conformations described in PSP might have some bearing on the interaction of PSP tau with certain populations of cells in distinct brain areas (Majumder and Dutta, 2024). Here, MAPT is linked to supranuclear palsy, progressive, 1.