The utilization of human tau variants associated with FTDP-17 mutations offers a viable approach for the creation of a murine model that faithfully recapitulates the pathological characteristics observed in human tauopathy.3,48 In this study, we succeeded in inducing overexpression of P301L mutated human tau by targeted insertion in Rosa26 and driving by Tet-off system. The gene discussed is MAPT; the disease is tauopathy.