Studies showed that alginate hydrogel loaded with the thymic stromal lymphopoietin (TSLP) and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) could upregulate the DC and FOXP3+ cells' number, which would hold promise to treat the upregulated pathologic inflammation of periodontal disease.71 This evidence concerns the gene TSLP and periodontal disorder.