PVALB and Alzheimer disease: The lateral entorhinal cortex has emerged as the key seed area for AD early synaptopathy; cell death can amount to 60% in mild AD, rising to 90% in demented patients and, importantly, preceded by excitatory-inhibitory synaptic disbalance resulting in synaptic hyperexcitability, attributable to the diminution of parvalbumin interneurons in animal models (Petrache et al., 2019).