APOE and Alzheimer disease: The fully-adjusted Cox proportional hazards model after adjusting for age, gender, education, APOE 4, cognitive diagnosis, SBP, and PP at T3 showed that higher SBPV was associated with increased risk of incident AD (HR = 1.28, 95% CI: 1.05 to 1.56, p = 0.012, Figure 2C).