This case presented the scenario of a patient with tall-cell variant of papillary thyroid carcinoma with two metastatic level VI lymph nodes (1.2 and 0.6 cm) who had undergone therapy with a RAI activity of 100 mCi in the previous year and had a rising serum thyroglobulin of 109 ng/mL. This evidence concerns the gene TG and differentiated thyroid carcinoma.