The possible relationships between the IRS1 gene rs1801276 variant with BMI, systolic blood pressure, diastolic blood pressure, hypertension, diabetes, aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transferase, steatosis, necroinflammation, and fibrosis in 123 NAFLD patients were also examined; no significant association was found (P ≥ 0.05). This evidence concerns the gene IRS1 and diabetes mellitus.