The possible relationships between the IRS1 gene rs1801276 variant with BMI, systolic blood pressure, diastolic blood pressure, hypertension, diabetes, aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transferase, steatosis, necroinflammation, and fibrosis in 123 NAFLD patients were also examined; no significant association was found (P ≥ 0.05). The gene discussed is IRS1; the disease is metabolic dysfunction-associated steatotic liver disease.