MTM1 and autosomal dominant centronuclear myopathy: In this context it is also of note that congenital disorders of autophagy show remarkable histopathological similarities with the myotubular/centronuclear myopathies due to variants in DNM2, BIN1, and MTM1, the latter in particular encoding a dual specificity phosphatase, myotubularin, with a crucial role in dephosphorylating the key second messenger lipids PI3P and PI3,5P2.93