Considering the RAS/MAPK pathway (54,55) and BCR-ABL1 fusion (56) both play important roles in chronic myeloid leukemia, and BRAF is a key factor of the RAS/MAPK pathway (57), our findings indicate the diverse patterns of clonal selection and mutual exclusion of driver mutations in chronic myeloid leukemia. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.