TREM2 and early-onset autosomal dominant Alzheimer disease: Microglia mitochondrial dysregulation occurring due to either reduced expression of TREM2 [118], increased P2 × 7R expression [119], reduced TSPO-hexokinase2 activity [120] or impaired mitophagy [121] have been extensively reviewed in the context of Alzheimer’s disease [122, 123].