Previous studies have suggested that the S100A protein in psoriatic tissues is synthesized by activated macrophages under inflammatory conditions (Batycka-Baran et al. 2015), and the role of fibroblasts in S100A8/A9 synthesis in psoriasis is poorly understood; however, the levels of these proteins are significantly increased in dermal fibroblasts, suggesting a specific role for fibroblasts in proinflammatory signaling leading to hyperproliferation of keratinocytes in psoriasis. The gene discussed is S100A1; the disease is psoriasis.