Through single-cell transcriptomic and spatial transcriptomic techniques, Ma (Ma et al. 2023) further revealed that in psoriasis, SFRP2+ fibroblasts transition from a fibrotic state to an inflammatory state by producing C-C motif chemokine ligand (CCL) 13, CCL19, C-X-C motif chemokine ligand (CXCL) 1, and CXCL12. Here, CXCL12 is linked to psoriasis.