Sidler (Sidler et al. 2017) reported that fibroblasts can respond to the effects of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) by expressing IL-19, which induces the expression of thymic stromal lymphopoietin (TSLP) and regulates many chemokines to affect the development of psoriasis and AD. Here, TSLP is linked to Alzheimer disease.