CD8A and melanoma: This process enhances ACSL4-mediated tumor ferroptosis triggered by the combined action of IFNγ and AA.118 In contrast, in mice with YUMM1.7 melanoma, the survival of Treg cells within the tumor is also reliant on CD36, implying notable variations in the regulation of T cell death among distinct subgroups.119 Overall, different T cell subsets exhibit varied responses to apoptotic signals, influencing the infiltration of CD8+ T cells, which can impact the progression of “cold” tumors.