On the contrary, blocking iron-induced cell death mediated by ACSL4 leads to a decrease in T cell-mediated immune responses against tumors.348 Additionally, stimulating ferroptosis through various nanoparticle-based methods enhances T cell infiltration in the tumor microenvironment.349,350 These findings underscore the potential enhancement of T cell-mediated immune responses towards tumors by simultaneously activating multiple pathways that induce ferroptosis. Here, ACSL4 is linked to neoplasm.