This observation implies the potential recruitment of Treg cells in conjunction with CD8+ T cells, a process that may disrupt the communication between CD8+ T cells and tumor cells.104 Additionally, a study revealed that in tumors, activated CXCR3+ Treg cells interact with BATF3+ DCs, leading to the production of CXCL9. This evidence concerns the gene CXCL9 and neoplasm.