CD274 and colorectal cancer: In ovarian and colorectal cancer cases, alterations in histone modifications and DNA methylation could lead to the suppression of CXCL9 and CXCL10 expression from TH1 cells.231,745 Focusing on epigenetic modulation holds promise for enhancing the functionality of effector T cells infiltrating tumors, halting tumor progression, and bolstering the effectiveness of PD-L1 inhibition in preclinical scenarios.745,746