CD4 and neoplasm: Consequently, selectively deleting Gpx4 in Treg cells could enhance anti-tumor immune responses by instigating ferroptosis.354 Follicular helper T (TFH) cells, a specific subset of CD4+ T cells known for promoting anti-tumor responses, display susceptibility to iron-induced apoptosis, akin to Treg cells.355 Further investigation is necessary to comprehend the interaction between ferroptosis and TFH cells in the tumor microenvironment.