CD8A and neoplasm: For instance, a nanoparticle complex named BO-112 consisting of Poly I:C and polyethyleneimine (PEI) induces type I interferon and CD8+ T cell infiltration into the tumor microenvironment, demonstrating potent anti-tumor activity.851 Studies have shown that local therapy with nanoparticles containing TLR7/8 agonists strongly activates macrophages, promoting proliferation of specific CD8+ T cells.852 Utilizing pH-responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with TLR7/8 agonists has enabled precise intratumoral drug delivery.