In murine models, the depletion of SLC7A11 impedes tumor progression while leaving in vivo T cell expansion and anti-tumor immunity unaffected, thereby enhancing the efficacy of immune checkpoint blockade in preclinical studies.347 Inducing ferroptosis, activated by cystine deficiency or arachidonic acid introduction, can also impede tumor progression without affecting the expansion and functionality of T cells in the TME. This evidence concerns the gene SLC7A11 and neoplasm.