NFKB1 and breast cancer: For instance, NF-κB activity induces the expression of CCL5, a chemokine that attracts macrophages expressing CCR5 and enhances collagen production, thereby promoting the proliferation of breast cancer cells.380 Activation of NF-κB in TAMs leads to the secretion of CCL22, which attracts CCR4+ Treg cells.381 Additionally, TAMs induce the release of CCL20 through NF-κB activation, recruiting CCR6+ Treg cells.382