Studies on tumor transplants suggest that tumor cells effectively exploit the cGAS-STING pathway to eliminate T cells, possibly through cGAMP release.185,186 Similarly, endothelial cells exhibit a tendency to undergo apoptosis when exposed to cGAS-STING triggers.187 The documented immune response modulation by various cell types may diminish the therapeutic efficacy of STING activation against tumors. This evidence concerns the gene STING1 and neoplasm.