To effectively activate CD8+ T cells and CD4+ T cells targeting TAAs, a series of chemokine-mediated interactions with both mobile and stationary DCs in various lymph node regions is essential.389 Notably, factors originating from tumors have the ability to suppress the production of the stromal cell-secreted chemokine CCL21 in lymph nodes responsible for tumor drainage. Here, CD8A is linked to neoplasm.