Specifically, CAFs induce monocyte migration and polarization towards M2 macrophages by releasing IL-8, resulting in the suppression of NK cell activity.489 Furthermore, the secretion of various cytokines by CAFs attracts monocytes to the TME, promoting their differentiation into M2 macrophages.491 Tumor progression is further supported by tumor-associated macrophages, which produce CXCL12 and IL-6 to enhance CAF function. The gene discussed is CXCL12; the disease is neoplasm.