STING1 and colorectal cancer: Subsequently, this process activates STING, leading to the secretion of type I interferons (IFNs) and pro-inflammatory cytokines.726 These elements, upon release, stimulate dendritic cells, thereby activating T cells and NK cells.170 The STING pathway is frequently suppressed in various cancer types, such as colorectal cancer and melanoma, contributing to a potent anti-tumor immune response.727,728 Activation of the cGAS-STING pathway has shown significant efficacy in inhibiting tumor metastasis.