Furthermore, blocking the anti-phagocytic signal mediated by CD47 can activate STING, leading to dendritic cell stimulation and CD8+ T cell activation.199,200 Blocking TIM3 can enhance DNA uptake by dendritic cells and modulate STING-mediated immune signaling.48 Similarly, defects in LC3-related autophagic processes are crucial for cellular balance and immune responses and can enhance T cell activation in a STING-dependent manner.201 Effective integration of cancer treatment methods that activate cGAS-STING activity is essential for treatment optimization. Here, CD8A is linked to cancer.