Tumors can be categorized into three primary immune phenotypes based on the distribution and abundance of cytotoxic immune cells in the TME: immune-infiltrated, immune-excluded, and immune-deserted.21,22 Immune-inflamed tumors, also known as “hot” tumors, are characterized by high levels of T cell infiltration, increased PD-L1 expression, and elevated tumor mutational burden (TMB), making them more responsive to immune checkpoint inhibitors. The gene discussed is CD274; the disease is neoplasm.