The cGAS-STING pathway is critical in various aspects of cancer progression, with a key role in regulating the senescence-associated secretory phenotype (SASP).175 This signaling pathway functions to suppress the proliferation of damaged cells and improve the elimination of precancerous cells by immune cells through cytokine signaling.176 Cells that manage to evade senescence face additional hurdles in transitioning to cancer, including replicative crisis characterized by telomere shortening, chromosomal abnormalities, and significant cell mortality. The gene discussed is CGAS; the disease is cancer.