Targeting MDA5 activation by including TLR3/ML8 agonists in nanoparticles has strengthened anti-tumor immunity, prolonged survival in a pancreatic cancer mouse model by increasing CD8+ T cell infiltration and immune cell activation.864 Additionally, the activation of the cGAS/STING pathway is crucial for cancer immunity and has been investigated as a promising therapeutic target. This evidence concerns the gene IFIH1 and familial pancreatic carcinoma.