In this context, the distinct structure of extracellular DNA generated in tumor cells can elicit a strong type I interferon response, as it relies on the cGAS-STING pathway.148 Considering the sustained presence of cGAS in the nucleus, the induction of nuclear DNA may also partly promote cGAS activation, although cytoplasmic sources are predominantly acknowledged.149. The gene discussed is STING1; the disease is neoplasm.