There is variation among Treg cells in tumors, with different Treg subsets dominating different stages of tumor development.393 In the context of infection, the ability of Treg cells to suppress T cell responses depends on their expression of specific transcription factors and chemokine receptors that correspond to various T cell subsets.394 Treg cells expressing CXCR3 gather in the TME before Treg cells expressing CCR4 and CCR8.395 The emergence of CXCR3+ Th1 and CD8+ T cells has raised questions about the recruitment of CXCR3+ Treg cells. This evidence concerns the gene CCR4 and neoplasm.