CGAS and colonic neoplasm: It has been proposed that cGAS accelerates tumorigenesis and increases DNA damage by interfering with homologous recombination DNA repair.190 Conversely, the absence of cGAS, regardless of STING, compromises the integrity of the intestinal barrier and impedes colon cancer progression, underscoring cGAS’s unique role in guarding against inflammation-induced tumorigenesis.191