Conversely, the predominant macrophages within tumor microenvironments (TAMs) belong to the M2 category, fostering tumorigenesis and displaying anti-inflammatory traits.736 Tumor-associated macrophages (TAMs) create a supportive tumor microenvironment (TME) conducive to tumor progression and metastasis by releasing growth factors, NF-κB, and pro-angiogenic agents. Here, NFKB1 is linked to neoplasm.