Research has demonstrated that the protein GTPase activator regulator of G protein 1 (RGS1) in tumor-specific circulating T cells acts as a suppressor of chemokine G protein-coupled receptors (GPCRs) signaling, leading to reduced T cell motility and decreased levels of infiltration by CTL and Th1 cells in mouse models, breast cancer, and lung cancer patients,66 underscoring the significance of regulating chemokine receptor function. This evidence concerns the gene CXCR6 and breast carcinoma.