Compared to “cold” tumors, “hot” tumors exhibit a higher mutational burden, leading to increased production of TAAs that enhance the immune system’s ability to recognize and eliminate tumor cells.385 In contrast to non-inflammatory tumors, inflammatory tumors demonstrate elevated expression of immunosuppressive genes like IDO, Foxp3, and PD-L1, activated as a response to positive anti-tumor immune reactions. This evidence concerns the gene IDO1 and neoplasm.