CD4 and neoplasm: “Hot” tumors are characterized by the abundant presence of CD4+ and CD8+ T cells surrounding tumor cells,383 emphasizing the critical need to effectively activate these anti-tumor T cells and produce a high concentration of T cell-attracting chemokines in the peritumoral lymph nodes.384 The positioning of T cells within tumors closely correlates with the expression of chemokines such as CCL2, CCL4, CCL5, CXCL9, and CXCL10.