Consequently, the abundance of cDC1 is limited, fostering tumor progression.376 Moreover, the decrease in cDC1 density within tumors over time implies that advanced tumors may possess the capacity to impede cDC1 migration.374 Whether a specific activation threshold is necessary to initiate CCR7-dependent migration of cDC1 towards tumors in sterile tissues remains unclear. The gene discussed is MPPE1; the disease is neoplasm.