The liberation of DAMPs amplifies the maturation of dendritic cells (DCs), enhances their ability to present antigens, promotes the secretion of cytokines like IL-2, IL-4, and IFN-γ, ultimately fostering an intensified anti-tumor immune response.750,751 Moreover, radiotherapy has the capability to provoke the release of inflammatory mediators such as interferons, interleukin-1β, and CXCL9. This evidence concerns the gene IFNG and neoplasm.