CGAS and cancer: Disruption of transcription networks by endogenous retrotransposon elements within the “viral response” process is observed to promote cancer progression.156,157 This process involves nucleic acids from activated retrotransposon elements participating in type I interferon responses through STING and mitochondrial antiviral signaling protein (MAVS) in tumor cells.158 Retrotransposon elements may compromise genome integrity, indirectly enhancing cGAS-STING activation, suggesting a potential strategy for enhancing cancer immunogenicity via epigenetic drugs.158