CD8A and neoplasm: Another form of T cell demise is ferroptosis, a pathway reliant on iron accumulation that triggers the generation of reactive oxygen species (ROS) and brings about cell death by lipid peroxidation of the cell membrane.116 Extending the longevity of CD8+ T cells is achievable by administering the ferroptosis inhibitor ferrostatin-1.117 CD36 enhances the ferroptosis process in CD8+ T cells by promoting lipid and fatty acid uptake from the tumor microenvironment (TME), leading to amplified lipid peroxidation and eventual cell death.116,117