CCL2 and neoplasm: Promising results have been demonstrated with targeted elimination of TAMs using strategies like dendritic polymer nanoparticles, bisphosphonate calcium nanoparticles, and silicon-coated gold nanoparticles.869 Furthermore, targeting signal-regulating monocytes derived macrophages infiltrating tumors with siRNA-loaded lipid or cationic polymer nanoparticles effectively promotes anti-tumor immune responses, such as through the CSF-1/CSF-1R and CCL2/CCR2 pathways.