TYRO3 and neoplasm: Nitric oxide radicals can effectively neutralize lipid radicals, thus protecting M1 macrophages from ferroptosis-induced damage.331 Iron nanoparticles have been shown to convert M2 macrophages into an M1 phenotype, enhancing their anti-cancer properties.332–334 Notably, the tyrosine protein kinase receptor TYRO3 significantly influences ferroptosis within the tumor microenvironment.