CGAS and cancer: Initially, the use of small molecule inhibitors to block cGAS or STING was primarily aimed at mitigating harmful inflammatory aspects linked to autoimmune disorders.188 Recent findings suggest that targeting cGAS or STING inhibition could play a pivotal role in preventing inflammation-induced tumor progression or serve as a therapeutic strategy against metastasis in cancers with high chromosomal instability.189 Lastly, cGAS is also believed to influence tumor progression and suppression independently of STING.