CCN2 and pancreatic neoplasm: However, the results have shown discrepancies.528 Another approach focuses on reducing the accumulation of hyaluronic acid (HA) in cancer, which mechanically increases stromal viscosity.529 Clinical trials testing drugs like PEGPH20, which target and inhibit HA, have shown diverse outcomes in various cancer treatments.530 Connective tissue growth factor (CTGF) promotes stromal deposition in cancer.531 Anti-CTGF therapy exhibits potential in reducing stromal accumulation in a pancreatic cancer mouse model.