The importance of these factors in facilitating monocyte recruitment to tumor sites and supporting their transformation into M2 macrophages is significant.490–496 Notably, TAMs play a crucial role in regulating the activation of CAFs through the secretion of CXCL12 and IL-6, initiating a beneficial feedback loop that promotes cancer progression.496 Neutrophils, similar to macrophages, are broadly categorized into two polarized subsets based on their phenotypic variances: the anti-tumor N1 neutrophils and the pro-tumor N2 neutrophils.497. The gene discussed is CXCL12; the disease is cancer.