TSHZ3 and hydronephrosis: Hydronephrosis and hydroureter were (significantly) more common in TSHZ3 variant carriers compared to non-carriers (6/12 (50%) versus 68/301 (23%), p = 0.039, and 4/12 (33%) versus 39/301 (13%), p = 0.067, two-tailed Fisher’s exact test, Fig. 2L).