TSHZ3 and congenital anomaly of kidney and urinary tract: Further evidence for a link between heterozygous TSHZ3 aberrations in humans and CAKUT, particularly hydronephrosis and hydroureter, come from two studies reporting hydronephrosis and ureteropelvic junction obstruction in one patient with a rare TSHZ3 missense variant, i.e., c.724G>C p.(Asp242His) [22], and speech delay, intellectual disability, behavioral issues, hydronephrosis, and mild urethral stenosis in a patient with a heterozygous TSHZ3 frameshift variant, i.e., c.119_120dup p.(Pro41SerfsTer79) [23].