This revealed that the expression of a set of genes critical for the characterization of CSC populations, such as CD44, NRP1, ZEB1, and NOTCH2, and a set of genes important for cancer progression and invasion, such as JAG1, ADAMTS1, and ACVR1, were specifically and significantly downregulated (Fig. 2A; Dataset EV2). The gene discussed is CD44; the disease is cancer.