MICAL3 and familial pancreatic carcinoma: Approaches that therapeutically target this niche have gained attention, such as treatment strategies targeting Wnt signaling in colorectal and pancreatic cancers and semaphorin signaling via MICAL3 in breast cancer (Barker et al, 2009; Schepers et al, 2012; Shimokawa et al, 2017; Steinhart et al, 2017; Tominaga et al, 2019).