In aged CD30//CD19-Cre mice with splenomegaly (17–19 months), the percentages of CD11b+ cells (primarily myeloid cells) and CD11c+ cells (predominantly dendritic cells) were significantly greater than those in aged control mice and middle-aged (~14 months) CD30//CD19-Cre mice (Supplementary Fig. 2). Here, TNFRSF8 is linked to Splenomegaly.