As a consequence, down-regulated voltage-gated calcium channels in CACNA1C, CACNA1G, CACNA1D1, and CACNA2D4, and purinergic receptors P2RX1 along with the down- regulated transcription factors including JUN and MYC can be attributed to reduced cell proliferation in keratoconus. Here, CACNA2D4 is linked to keratoconus.