ORAI1 and Thrombocytopenia: Additional multi-systemic manifestations, including thrombocytopenia and hyposplenism, are observed in some individuals with TAM (typically in individuals with mutations in STIM1, but not ORAI1), which reflects in a clinical continuum with Stormorken and York Platelet Syndrome (Bohm et al, 2017; Bohm et al, 2013; Endo et al, 2015; Garibaldi et al, 2017; Harris et al, 2017; Hedberg et al, 2014; Misceo et al, 2014; Stormorken et al, 1985; Walter et al, 2015).