As demonstrated by the results of western blot, restoration of NF90 expression partially rescued the TRIM55-mediated downregulation of HIF1α, TGF-β2 and P-Smad2 expression (Fig. 8I), suggesting that TRIM55 regulated HIF1α and TGF-β2 partially via NF90 in HCC cells. Here, SMAD2 is linked to hepatocellular carcinoma.