EGF and colorectal carcinoma: Indeed, the gene expression analysis of cultured CRC cells unveiled that Batimastat effectively suppressed HB-EGF, miR-221, ADAM9, and the chemokine ligand 2 (CCL2),—another miR-126 target gene and known macrophage chemokinetic factor expression in miR-126 OE and Mock, but less in miR-126 KD cells (Fig. 4F).