HBEGF and neoplasm: Of interest, the analysis of tumor-derived macrophages isolated from miR-126 OE tumors in mice treated with Batimastat showed the lowest HB-EGF (Fig. 5I), suggesting that the combined treatment of miR-126 reintroduction and Batimastat suppresses HB-EGF expression in tumor and inflammatory cells in the tumor niche that might indirectly in a paracrine fashion contribute to tumor growth suppression.