In contrast, the expression of the three endogenous MMPi called tissue inhibitors of metalloproteinase (TIMP)-1, -2, and -3 [22] was similar in miR-126 OE compared to Mock cells (Supplementary Fig. 2B), indicating that miR-126 restoration in CRC cells suppressed proteases like MMP7 and -9 but not their endogenous inhibitors. Here, TIMP1 is linked to colorectal carcinoma.