PD-linked mutations in the kinase LRRK2 cause neurite shortening [34, 51], endo-lysosomal pathway impairment [20, 21, 40], and ciliogenesis and centrosomal cohesion deficits through hyper-phosphorylation of Rab10 and Rab8a [24, 27, 29, 30]. This evidence concerns the gene LRRK2 and Parkinson disease.