Interestingly, we observed that XCL1-expressing dysplastic cells in the submucosal gland in most of the cases are completely separated from the squamous cell carcinoma, suggesting that this subgroup of patients might concurrently have both squamous cell carcinoma and adenocarcinoma, or this adenosquamous carcinoma might be derived from submucosa gland epithelial cells. Here, XCL1 is linked to adenosquamous carcinoma.