To this end, many previous studies highlighted and focused on osteoclastogenesis.43 A series of murine models targeted at osteoclastic function were constructed to mimic osteopetrosis,44 the edited genes of which can divided into two main groups: proteins expressed in osteoclasts (e.g. CLCN7) and proteins that induce osteoclastogenesis (e.g. M-CSF). This evidence concerns the gene CLCN7 and osteopetrosis.