Furthermore, in the LK lineage, the CMPs and MEPs were decreased in the BM of the OsxCre;R26dn/dn mice (Fig. 5h), which may be related to the anemia and haemorrhagia in osteopetrosis patients.34 Additionally, immunohistochemistry staining showed a decrease of SCF+ cells, further supporting the impairment of hematopoietic progenitor differentiation (Fig. 5i). This evidence concerns the gene KITLG and anemia (phenotype).