Low expression of let-7b and let-7c derived from esophageal cancer tissues before preoperative cisplatin-based chemotherapy is correlated with poor pathologic tissue response by regulating the interleukin-6/STAT3 pathway.31In vitro research has shown that decreased let-7b promotes the proliferation and motility of esophageal cancer cell lines via KIAA1377 and that let-7b expression suppresses esophageal cancer cell lines.32 This evidence concerns the gene IL6 and esophageal cancer.