CEACAM5 and neoplasm: Similarly, high CEA levels were reported to be a poor prognostic factor in a nationwide multicenter retrospective study by the Japanese Esophageal Society.42 To our knowledge, there are no reports on the usefulness of CEA in predicting pCR, but pCR is considered a prognostic surrogate maker, and a high CEA level may indicate a high probability of tumor remnant.