For example, spheroids formed by Lung KP cells (derived from a murine model of lung adenocarcinoma driven by KRASG12D and loss of TP53 [Sánchez-Rivera et al, 2014]) displayed a strong gradient of GFP that increased with the distance to the opening of the 3MIC (Fig S1C). The gene discussed is TP53; the disease is lung adenocarcinoma.