Strikingly, while the number of antigenic epitopes expressed by the ZIKV-NS differs greatly according to the HLA class I alleles, with 16 epitopes identified in HLA-A*2402 transgenic mice versus 5 epitopes identified in HLA-B*0702 transgenic mice, both types of transgenic mice are protected against ZIKV infection after vaccination with ZIKV-NS. Here, HLA-B is linked to Zika virus infectious disease.