Later, Paci et al. [16] found three network modules in a COPD co-expression network; one of these modules included a COPD GWAS gene (AGER) and a COPD lung protein biomarker CAVIN1 [17]as highly representative genes, supporting the hypothesis of coordinated changes to gene expression levels in COPD patients. Here, CAVIN1 is linked to chronic obstructive pulmonary disease.