In Maturation stages of T cell group, CD45RA-CD4+%CD4+(P = 0.035, OR = 1.029, 95%CI = 1.002~1.058) and EM CD4+AC (P = 0.021, OR = 1.024, 95%CI = 1.003~1.045) were positively correlated with breast cancer. This evidence concerns the gene CD4 and breast cancer.