HGF is a growth factor that can be produced by tumor stromal cells and plays an important role in promoting malignant tumor progression and metastasis [32, 33], with the HGF/c-Met signaling pathway being the most classical pathway in which it functions [34–36], and the specific binding of HGF to c-Met triggers a series of responses that promote cell migration, induce angiogenesis and promote stromal degradation and invasiveness. This evidence concerns the gene HGF and neoplasm.