The full name of ECM1 is extracellular matrix protein 1, and studies have shown that this gene is overexpressed in many malignancies of epithelial origin, including colorectal, thyroid, and hepatocellular carcinomas [24, 25], and also breast cancer [26, 27].Overexpression of ECM1 can promote the stemness phenotype of tumor cells as well as the EMT process [28]. The gene discussed is ECM1; the disease is hepatocellular carcinoma.