TNF and Intervertebral disk degeneration: The analysis revealed through macrogenetic research of intestinal flora that DHJSD may modulate TNF, NF-kappa B, PI3K-Akt, MAPK signaling pathways through CASP8, TNF-α, IL-3, and other crucial proteins to inhibit apoptosis in the nucleus pulposus and treat rat intervertebral disc degeneration.