GK and hepatocellular carcinoma: Consistent with our results, overexpression of human GK in a rat hepatoma cell line resulted in significantly increased SREBP‐1 mRNA and lipid accumulation in the cells.[29] It has been reported that upregulation of DGAT2 expression may promote lipogenesis by regulating cleavage of SREBP‐1c precursor protein.[30] Therefore, GK may also promote lipogenesis and TG synthesis by regulating SREBP‐1c processing through DGAT2 in hepatocytes.