Since knockdown of hepatic Gk in mice with HFD‐induced hepatic steatosis significantly reduced the expression of Srebp‐1c and its target lipogenic genes and TG synthesis genes (Figure 1L–P), we investigated the relationship between the expression of hepatic Gk and Srebp‐1c in mouse models of NAFL induced by either diet or leptin/leptin receptor gene mutation. This evidence concerns the gene LEP and fatty liver disease.