GK plays an important role in glucose homeostasis under physiological conditions and contributes to hyperglycemia in diabetic mice.[15] We found that hepatic GK was upregulated in HFD‐induced obese mice with hyperglycemia and hyperlipidemia.[15] However, it's not clear whether GK contributes to lipid homeostasis under physiological and to the development of NAFL. This evidence concerns the gene GK and hyperlipidemia.