EPHX2 and acute pancreatitis: For instance, Bettaieb et al. demonstrated in a murine model of acute pancreatitis that sEH inhibition by TPPU significantly downregulated expression of Il1b, Il6, and Tnf in the pancreas, as well as protein levels of IL-1β, IL-6, and TNF-α in the plasma, up to 48 h after induction of pancreatitis (Bettaieb et al. 2015).