TNF and relapsing-remitting multiple sclerosis: Similar NK cell phenotypes associated with favorable disease outcomes have been reported in the literature, such as CD8+CD57+ NK cells associated with slower HIV-1 disease progression (28), a CD8+ NK cell transcriptomic signature associated with periods of remission in relapsing remitting multiple sclerosis (29), and CD8+ NK cells associated with response to anti–TNF-α therapy in ankylosing spondylitis (30).