Finally, given that coexpression of CD57 and CD8 defined a subset of NK cells that were expanded in the blood of patients with RA in stable remission, we analyzed whether the proportion of CD107a+IFN-γ+TNF-α+ polyfunctional subsets was different between CD8– and CD8+ subsets (Supplemental Figure 5A) and CD57– and CD57+ subsets (Supplemental Figure 5B). This evidence concerns the gene TNF and rheumatoid arthritis.