SREBF2 and ductal breast carcinoma in situ: The cellular cholesterol level reflects the dynamic balance between biosynthesis, transport, and esterification—a process in which cholesterol is converted to bile acids, vitamins, and steroid hormones eventually.[33, 34, 35] The correlation analysis results showed a significantly positive correlation between SREBF2 and the steroid hormone biosynthesis enrichment score (Spearman rho = 0.37, p = 2.35e‐05), suggesting that synthetic cholesterol may be metabolized into steroid hormones in DCIS (Figure 2K).