In conclusion, from DH to DCIS_Pure, 6q21 gain increases PRDM1 expression and further upregulate NR3C1 expression, resulting in the downregulation expression of CX3CL1 and CXCL12 by inhibiting the pathway of TNF‐α signaling via NFκB. The downregulated expression of CX3CL1 and CXCL12 leads to the reduction of their chemotaxis to CD8+ T cells, thus resulting in immune escape of tumor cells in DCIS_Pure (Figure 3K). Here, TNF is linked to neoplasm.