Subsequently, we found that compared with the wild‐type TP53 group and DH, cholesterol biosynthesis‐related proteins ((lanosterol synthase (LSS), sterol‐C5‐desaturase (SC5D), and mevalonate diphosphate decarboxylase (MVD)) were upregulated in the TP53 mutation group and DCIS both in mRNA and protein levels (Student's t‐test, p < 0.05) (Figure 2I,J). The gene discussed is SC5D; the disease is ductal breast carcinoma in situ.