Pathway scores based on global proteomics data obtained by single‐sample gene set variation analysis (ssGSEA)[29, 30] demonstrated the cholesterol homeostasis pathway was significantly upregulated in the TP53 mutation group and DCIS compared with the wild‐type TP53 group and DH, respectively (Student's t‐test, p < 0.05) (Figure 2E). This evidence concerns the gene TP53 and ductal breast carcinoma in situ.