AKR1C1 is a member of the AKR1C family and was reported to be highly expressed in different cancer types such as breast cancer, gastric cancer, bladder cancer, and non‐SCLC.[94, 95, 96, 97] The overexpression of AKR1C1 often plays an essential role in cancer invasion, metastasis, and chemoresistance.[96] Here, we found that AKR1C1 could remove excess ROS in DCIS_adjIDC cells, leading to preventing the apoptosis of tumor cells and promoting migration of tumor cells. The gene discussed is AKR1C1; the disease is small cell lung carcinoma.